Postdoctoral fellow -- structure biology, biochemistry or cell biology at Washington University in St. Louis

Washington University in St Louis Medical School

Saint Louis, MO

Job posting number: #7072673

Posted: November 30, 2020

Job Description

A postdoc position is immediately available for a highly motivated individual to study membrane enzymes, transporters and adhesion molecules that are important therapeutic targets in hematology and cardiovascular biology. To support the study, Dr. Weikai Li’s lab at Washington University in St. Louis has developed multidisciplinary approaches that combine novel structural biology and mass spectrometry methods with biochemistry and cell biology. Recent publications of the lab include those in Science, Science Adv., EMBO J and NSMB. The lab is well funded by five grants from NIH and other foundations, which can support the entire duration of postdoctoral study. More information of the lab can be found at https://weikailab.wustl.edu.

Requirements and Responsibilities
The postdoc candidate should have strong background and publication record in either structural biology, biochemistry or cell biology. Based on previous experiences, the postdoc may choose to work on cryo-EM and crystal structures of membrane proteins, study their biochemistry and cell biology, or combine with mass spectrometry to elucidate their native states and interactions.

Current projects in the lab include:
• Cryo-EM and crystal structures of several membrane proteins and complexes important in hematology and cardiovascular biology.
• Development of Cryo-EM methods to readily solve structures of most membrane proteins.
• The degradation pathway of ferroportin (the only iron exporter) and its protective role of cardiomyocytes.
• How cellular interactions of tetraspanin CD53 regulate B cell trafficking.
• The cellular organization of tight junction formation mediated by claudins and associated molecules.
Furthermore, the lab culture encourages free exploration, and the fellow is welcome to develop their own research projects and strategies that are of mutual interest. High degrees of motivation and independency are greatly appreciated. On the other hand, the PI is always available to provide advices.

Research Environment: The Washington University Medical School is top ranked in the US. The Li lab is well established and equipped in the structural biology, mass spectrometry, biochemistry, and cell biology studies of membrane proteins, and has developed novel methods for these studies, such as live cell footprinting (NSMB 2007) and fast structure determination (Sci. Adv. 2020). For cryo-EM, the lab gets regular time (about one week in every two months) in using Washington University’s own Titan Krios. Crystallization robots and regular APS time are available for crystallography studies. Close collaboration with Dr. Michael Gross lab affords us extensive access to mass spectrometry analyses.

Please send your CV, the name of three references, and a brief email detailing your research interest to weikai@wustl.edu.

Weikai Li, Ph. D.
Associate Professor
Department of Biochemistry and Molecular Biophysics
School of Medicine, Washington University in St. Louis

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Job posting number:#7072673
Application Deadline:Open Until Filled
Employer Location:Washington University in St Louis
St. Louis,Missouri
United States
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