Sanford Burnham Prebys is a preeminent, independent Biomedical Research Institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health.
A Staff Scientist position is available in the laboratory of Dr. Pamela Itkin-Ansari to study proinsulin protein-protein interactions in diabetes. We are investigating the hypothesis that alterations in the proinsulin interaction network play a role in Endoplasmic Reticulum (ER) stress and beta-cell failure. The position is based on our recent studies in Diabetes, ELife, and JCEM. The long-term goal of this project is to develop a novel paradigm for improving ER function and proinsulin trafficking in beta-cells to prevent or ameliorate diabetes.
Duties and Responsibilities:
The successful applicant will be independent enough to generate hypotheses, design experiments, interpret data, trouble shoot, optimize and accurately document experiments. They must be able to analyze and interpret data from different sources and draw relevant conclusions, present results at internal and external meetings and contribute to the writing of reports and manuscripts.
Required skills include tissue culture, expression analysis, immunoprecipitation-Western blots, gene knock-down approaches, immunohistochemistry, RNA preparation, gene cloning, PCR, GSIS measurement.
The applicant must work well with others as part of our collaboration with the Kaufman and Arvan labs. The applicant must be familiar with and stay current with relevant literature in order to keep the project moving forward.
Education and/or Experience:
The candidate must have a Ph.D. degree in the Biological Sciences or an M.D. and must have experience in islet biology. They must have an understanding of islet physiology and experience studying ER chaperones, the effect of cytokines on islets and islet cell death.
Knowledge, Skills and/or Abilities:
Experience in proteomics and knowledge of R/working with big datasets and are desirable. Have strong organizational and problem-solving skills. Excellent data presentation,verbal,and written communication skills. Possess strong attention to detail, analytical, time management, and interpersonal skills. Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion
Proof of COVID-19 vaccination required
The expected hiring range for this position is $675,000 - 8$85,000, commensurate with experience.
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.
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