Job Description
JOIN US MARCH 5th! You’re invited to a live virtual presentation featuring Ajay Goel, Ph.D., AGAF hosted by City of Hope to share insights on his research and provide valuable information to candidates for his programs during this 20-minute live presentation! Stay for the Q & A session immediately following. We begin at 2 pm and you must register to join: http://tinyurl.com/2p7yj9vx Bring your resume’, your questions and a friend! *All are welcome.
More about Dr Goel here: Ajay Goel, Ph.D., AGAF, Chair, Department of Molecular Diagnostics and Experimental Therapeutics | Beckman Research Institute of City of Hope
Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
A Postdoctoral Fellowship opportunity is immediately available for a highly motivated individual in the laboratory of Dr. Larry Kwak. For more information on Dr. Kwak’s research please visit here.
As a successful candidate, you will:
· Study pre-clinical study for a personalized mRNA cancer vaccine against lymphoma.
· Use single-cell RNA analysis, you will study cell-intrinsic characteristics of BAFF-R CAR-T correlated with responses that can be used as markers of clinical outcomes.
· Skills that are used in the lab include: working with mice, mammalian cell culture, primary human cell (BM and PBMC) culture and handling, multi-color FLOW cytometry, ELISA, and cell-sorting, co-culture functional assays.
· Be familiar with novel single-cell RNA sequencing technologies and analysis pipelines.
· Highly motivated and self-directed applicants interested in translational research in cancer immunotherapy are strongly encouraged to apply. However, applicants with related training and experience will be given priority.
· Ph.D. degree with research experience; a track record of publications in peer-reviewed scientific journals.
· Strong background in immune-oncology, vaccinology and/or immunology.
· Expertise in multi-parameter FLOW cytometry.
· Expertise in cell-based assays (e.g. co-culture functional assays, multi-color flow cytometry, ELISA, cell sorting, etc.)
· Experience executing primary immune cell assays and mechanism of action studies (T cell isolation, expansion, cytokine secretion assays, T cell differentiation, T cell killing assay etc).
Additional Information:
For more scientific background, please refer to our publications:
o Science 2002 Nov 1; 298(5595):1025-9: https://doi.org/10.1126/science.1075565
o Nature Medicine 2005 Sep; 11(9): 986-91: https://doi.org/10.1038/nm1290
o BMC Cancer 2018 Feb 13;18(1): https://doi.org/10.1186/s12885-018-4094-2
o Sci Transl Med 2019 Sep 25. https://doi.org/10.1126/scitranslmed.aaw9414
o Blood volume 136, Supplement 1 2020 Nov https://doi.org/10.1182/blood-2020-140007
o Blood 2022 Mar 3 https://doi.org/10.1182/blood.2020008493
City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here
Salary / Pay Rate Information:
Pay Rate: $31.00 - $34.23 / hour
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.
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